Guffo hails from Monterrey in Mexico, where he used to work as a political cartoonist for several newspapers. He also worked as a prison warden for three years. This is where Guffo was faced with the human rights crisis for the first time.
Now an independent cartoonist, Guffo does the best he can to contribute to a better world. His main concern is to protect the environment: Guffo has participated in several exhibitions where his drawings contained an ecological theme, such as trees that are given away for free to be planted.